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2roy
From Proteopedia
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TRANSTHYRETIN (ALSO CALLED PREALBUMIN) COMPLEX WITH 3',5'-DINITRO-N-ACETYL-L-THYRONINE
Overview
The molecular structures of two human transthyretin (hTTR, prealbumin), complexes, co-crystallized with thyroxine, (3,5,3',5'-tetraiodo-L-thyronine; T(4)), and with, 3',5'-dinitro-N-acetyl-LL-thyronine (DNNAT), were determined by X-ray, diffraction methods. Crystals of both structures are orthorhombic, space, group P2(1)2(1)2, and have two independent monomers in the asymmetric unit, of the crystal lattice. These structures have been refined to 17.0% for, 8-2.0 A resolution data for the T(4) complex (I), and to R = 18.4% for, 8-2.2 A resolution data for the DNNAT structure (II). This report provides, a detailed description of T(4) binding to wild-type hTTR at 2.0 A, resolution, as well as DNNAT. In both structures, the two independent, hormone-binding sites of the TTR tetramer are ... [(full description)]
About this Structure
2ROY is a [Single protein] structure of sequence from [Homo sapiens] with P28 as [ligand]. This structure superseeds the now removed PDB entry 1ROY. Full crystallographic information is available from [OCA].
Reference
Structures of human transthyretin complexed with thyroxine at 2.0 A resolution and 3',5'-dinitro-N-acetyl-L-thyronine at 2.2 A resolution., Wojtczak A, Cody V, Luft JR, Pangborn W, Acta Crystallogr D Biol Crystallogr. 1996 Jul 1;52(Pt 4):758-65. PMID:15299640
Page seeded by OCA on Mon Oct 29 20:10:35 2007
Categories: Homo sapiens | Single protein | Cody, V. | Luft, J.R. | Pangborn, W. | Wojtczak, A. | P28 | Albumin | Amyloid | Cerebrospinal fluid | Disease mutation | Liver | Plasma | Polymorphism | Polyneuropathy | Prealbumin | Retinol-binding | Signal | Thyroid hormone | Thyroxine | Transport | Vitamin a
