1k4r
From Proteopedia
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Structure of Dengue Virus
Overview
The first structure of a flavivirus has been determined by using a, combination of cryoelectron microscopy and fitting of the known structure, of glycoprotein E into the electron density map. The virus core, within a, lipid bilayer, has a less-ordered structure than the external, icosahedral, scaffold of 90 glycoprotein E dimers. The three E monomers per icosahedral, asymmetric unit do not have quasiequivalent symmetric environments., Difference maps indicate the location of the small membrane protein M, relative to the overlaying scaffold of E dimers. The structure suggests, that flaviviruses, and by analogy also alphaviruses, employ a fusion, mechanism in which the distal beta barrels of domain II of the, glycoprotein E are inserted into the cellular membrane.
About this Structure
1K4R is a Single protein structure of sequence from Tick-borne encephalitis virus. Full crystallographic information is available from OCA.
Reference
Structure of dengue virus: implications for flavivirus organization, maturation, and fusion., Kuhn RJ, Zhang W, Rossmann MG, Pletnev SV, Corver J, Lenches E, Jones CT, Mukhopadhyay S, Chipman PR, Strauss EG, Baker TS, Strauss JH, Cell. 2002 Mar 8;108(5):717-25. PMID:11893341
Page seeded by OCA on Tue Nov 20 18:51:50 2007
Categories: Single protein | Tick-borne encephalitis virus | Baker, T.S. | Chipman, P.R. | Corver, J. | Jones, C.T. | Kuhn, R.J. | Lenches, E. | Mukhopadhyay, S. | Pletnev, S.V. | Rossmann, M.G. | Strauss, E.G. | Strauss, J.H. | Zhang, W. | Dengue virus | Flaviviridae | Flavivirus | Glycoprotein e from tick-borne encephalitis virus | Icosahedral virus
