1kaw
From Proteopedia
|
STRUCTURE OF SINGLE STRANDED DNA BINDING PROTEIN (SSB)
Overview
The crystal structure of the tetrameric DNA-binding domain of the, single-stranded DNA binding protein from Escherichia coli was determined, at a resolution of 2.9 A using multiwavelength anomalous dispersion. Each, monomer in the tetramer is topologically similar to an oligomer-binding, fold. Two monomers each contribute three beta-strands to a single, six-stranded beta-sheet to form a dimer. Two dimer-dimer interfaces are, observed within the crystal. One of these stabilizes the tetramer in, solution. The other interface promotes a superhelical structure within the, crystal that may reflect tetramer-tetramer interactions involved in the, positive cooperative binding of the single-stranded DNA-binding protein to, single-stranded DNA.
About this Structure
1KAW is a Single protein structure of sequence from Escherichia coli. Full crystallographic information is available from OCA.
Reference
Crystal structure of the homo-tetrameric DNA binding domain of Escherichia coli single-stranded DNA-binding protein determined by multiwavelength x-ray diffraction on the selenomethionyl protein at 2.9-A resolution., Raghunathan S, Ricard CS, Lohman TM, Waksman G, Proc Natl Acad Sci U S A. 1997 Jun 24;94(13):6652-7. PMID:9192620
Page seeded by OCA on Tue Nov 20 19:00:37 2007
