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1kn3
From Proteopedia
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Murine PEBP-2 (phosphatidylethanolamine-binding protein-2)
Overview
Proteins from the PEBP (phosphatidylethanolamine-binding protein) family, have been identified in a wide variety of species and are thought to, regulate a range of intracellular signalling cascades. The rat homologue, (known as RKIP; Raf-1 kinase inhibitor protein) has been shown to, negatively regulate the MAP kinase pathway through formation of inhibitory, complexes with Raf-1 and MEK. The crystal structure of a new, murine, member of the PEBP family, termed mPEBP-2, has been determined. On the, basis of amino-acid homology, mPEBP-2 belongs to a distinct subset of the, mammalian PEBP proteins. Nonetheless, mPEBP-2 is seen to be very similar, in structure to other PEBP proteins from human, bovine and plant sources., Regions of distinctive sequence associated with the PEBP-2 subset are, discussed with reference to this structure.
About this Structure
1KN3 is a Single protein structure of sequence from Mus musculus. Full crystallographic information is available from OCA.
Reference
The crystal structure of PEBP-2, a homologue of the PEBP/RKIP family., Simister PC, Banfield MJ, Brady RL, Acta Crystallogr D Biol Crystallogr. 2002 Jun;58(Pt 6 Pt 2):1077-80. Epub, 2002 May 29. PMID:12037323
Page seeded by OCA on Tue Nov 20 19:22:43 2007
