2pgq

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Image:2pgq.png

Template:STRUCTURE 2pgq

Contents

Human thrombin mutant C191A-C220A in complex with the inhibitor PPACK

Template:ABSTRACT PUBMED 17636263

Disease

Known disease associated with this structure: Dysprothrombinemia OMIM:[176930], Hyperprothrombinemia OMIM:[176930], Hypoprothrombinemia OMIM:[176930]

About this Structure

2PGQ is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Important role of the cys-191 cys-220 disulfide bond in thrombin function and allostery., Bush-Pelc LA, Marino F, Chen Z, Pineda AO, Mathews FS, Di Cera E, J Biol Chem. 2007 Sep 14;282(37):27165-70. Epub 2007 Jul 18. PMID:17636263

Molecular dissection of Na+ binding to thrombin., Pineda AO, Carrell CJ, Bush LA, Prasad S, Caccia S, Chen ZW, Mathews FS, Di Cera E, J Biol Chem. 2004 Jul 23;279(30):31842-53. Epub 2004 May 19. PMID:15152000

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