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2oj9

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Image:2oj9.png

Template:STRUCTURE 2oj9

Contents

Structure of IGF-1R kinase domain complexed with a benzimidazole inhibitor

Template:ABSTRACT PUBMED 17317169

Disease

Known disease associated with this structure: Intrauterine and postnatal growth retardation OMIM:[147370]

About this Structure

2OJ9 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Discovery and initial SAR of 3-(1H-benzo[d]imidazol-2-yl)pyridin-2(1H)-ones as inhibitors of insulin-like growth factor 1-receptor (IGF-1R)., Velaparthi U, Wittman M, Liu P, Stoffan K, Zimmermann K, Sang X, Carboni J, Li A, Attar R, Gottardis M, Greer A, Chang CY, Jacobsen BL, Sack JS, Sun Y, Langley DR, Balasubramanian B, Vyas D, Bioorg Med Chem Lett. 2007 Apr 15;17(8):2317-21. Epub 2007 Feb 4. PMID:17317169

Page seeded by OCA on Sun Jul 27 19:51:28 2008

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