3lkf
From Proteopedia
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LEUKOCIDIN F (HLGB) FROM STAPHYLOCOCCUS AUREUS WITH PHOSPHOCHOLINE BOUND
Overview
Staphylococcal LukF, LukS, HgammaII, and alpha-hemolysin are, self-assembling, channel-forming proteins related in sequence and, function. In the alpha-hemolysin heptamer, the channel-forming, beta-strands and the amino latch make long excursions from the protomer, core. Here we report the crystal structure of the water soluble form of, LukF. In the LukF structure the channel-forming region folds into an, amphipathic, three-strand beta-sheet and the amino latch forms a, beta-strand extending a central beta-sheet. The LukF structure illustrates, how a channel-forming toxin masks protein-protein and protein-membrane, interfaces prior to cell binding and assembly, and together with the, alpha-hemolysin heptamer structure, they define the end points on the, pathway of toxin assembly.
About this Structure
3LKF is a Single protein structure of sequence from Staphylococcus aureus with PC as ligand. Full crystallographic information is available from OCA.
Reference
Crystal structure of staphylococcal LukF delineates conformational changes accompanying formation of a transmembrane channel., Olson R, Nariya H, Yokota K, Kamio Y, Gouaux E, Nat Struct Biol. 1999 Feb;6(2):134-40. PMID:10048924
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