1kut

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spinqualitylabelsall models 1kut, resolution 2.20Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image

Structural Genomics, Protein TM1243, (SAICAR synthetase)

Overview

As a part of a structural genomics program, the 2.2 angstroms resolution, crystal structure of the PurC gene product from Thermotoga maritima has, been solved. This 26.2 kDa protein belongs to the, phophoribosylaminoimidazole-succinocarboxamide or SAICAR synthase family, of enzymes, the members of which are involved in de novo purine, biosynthesis. SAICAR synthase can be divided into three subdomains: two, alpha+beta regions exhibiting structural homology with ATP-binding, proteins and a carboxy-terminal subdomain of two alpha-helices. The, asymmetric unit contains two copies of the protein which are covalently, linked by a disulfide bond between Cys126(A) and Cys126(B). This, 230-amino-acid protein exhibits high structural homology with SAICAR, synthase from baker's yeast. The protein structure is described and, compared with that of the ATP-SAICAR synthase complex from yeast.

About this Structure

1KUT is a Single protein structure of sequence from Thermotoga maritima. Active as Phosphoribosylaminoimidazolesuccinocarboxamide synthase, with EC number 6.3.2.6 Full crystallographic information is available from OCA.

Reference

Structure of SAICAR synthase from Thermotoga maritima at 2.2 angstroms reveals an unusual covalent dimer., Zhang R, Skarina T, Evdokimova E, Edwards A, Savchenko A, Laskowski R, Cuff ME, Joachimiak A, Acta Crystallograph Sect F Struct Biol Cryst Commun. 2006 Apr 1;62(Pt, 4):335-9. Epub 2006 Mar 25. PMID:16582479

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