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3cd8

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Image:3cd8.png

Template:STRUCTURE 3cd8

Contents

X-ray Structure of c-Met with triazolopyridazine Inhibitor.

Template:ABSTRACT PUBMED 18426196

Disease

Known disease associated with this structure: Hepatocellular carcinoma, childhood type OMIM:[164860], Renal cell carcinoma, papillary, familial and sporadic OMIM:[164860], Autism, suseptibility to, 9 OMIM:[164860]

About this Structure

3CD8 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Discovery and Optimization of Triazolopyridazines as Potent and Selective Inhibitors of the c-Met Kinase., Albrecht BK, Harmange JC, Bauer D, Berry L, Bode C, Boezio AA, Chen A, Choquette D, Dussault I, Fridrich C, Hirai S, Hoffman D, Larrow JF, Kaplan-Lefko P, Lin J, Lohman J, Long AM, Moriguchi J, O'Connor A, Potashman MH, Reese M, Rex K, Siegmund A, Shah K, Shimanovich R, Springer SK, Teffera Y, Yang Y, Zhang Y, Bellon SF, J Med Chem. 2008 May 22;51(10):2879-82. Epub 2008 Apr 22. PMID:18426196

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