1bx4

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spinqualitylabelsall models 1bx4, resolution 1.50Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image

STRUCTURE OF HUMAN ADENOSINE KINASE AT 1.50 ANGSTROMS

Overview

Adenosine kinase (AK) is a key enzyme in the regulation of extracellular, adenosine and intracellular adenylate levels. Inhibitors of adenosine, kinase elevate adenosine to levels that activate nearby adenosine, receptors and produce a wide variety of therapeutically beneficial, activities. Accordingly, AK is a promising target for new analgesic, neuroprotective, and cardioprotective agents. We determined the structure, of human adenosine kinase by X-ray crystallography using MAD phasing, techniques and refined the structure to 1.5 A resolution. The enzyme, structure consisted of one large alpha/beta domain with nine beta-strands, eight alpha-helices, and one small alpha/beta-domain with five, beta-strands and two alpha-helices. The active site is formed along the, edge of the beta-sheet ... [(full description)]

About this Structure

1BX4 is a [Single protein] structure of sequence from [Homo sapiens] with CL, MG and ADN as [ligands]. Active as [[1]], with EC number [2.7.1.20]. Full crystallographic information is available from [OCA].

Reference

Structure of human adenosine kinase at 1.5 A resolution., Mathews II, Erion MD, Ealick SE, Biochemistry. 1998 Nov 10;37(45):15607-20. PMID:9843365

Page seeded by OCA on Mon Oct 29 20:22:50 2007