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1lof
From Proteopedia
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X-RAY STRUCTURE OF A BIANTENNARY OCTASACCHARIDE-LECTIN COMPLEX AT 2.3 ANGSTROMS RESOLUTION
Overview
The structure and flexibility of saccharides have a profound and specific, influence in several biological processes such as protein protection and, the maintenance of conformational integrity, and in recognition events, involving viruses, enzymes, and lectins. To establish the structural bases, of these phenomena, we describe herein the extensively refined 2.3-A, resolution x-ray structure of a biantennary octasaccharide of the, N-acetyllactosamine type, complexed to isolectin I from Lathyrus ochrus., The two octasaccharides are located in clefts at each end of the long axis, of the lectin. The conformations of both the lectin and the saccharide are, slightly modified upon binding. The complex is stabilized by numerous, hydrogen bonds, many of them involving water molecules. It is also, stabilized by van der Waals interactions, including some with aromatic, residues. A more general model of a possible lectin-glycoprotein, interaction is also proposed.
About this Structure
1LOF is a Protein complex structure of sequences from Lathyrus ochrus with GAL, CA and MN as ligands. Full crystallographic information is available from OCA.
Reference
X-ray structure of a biantennary octasaccharide-lectin complex refined at 2.3-A resolution., Bourne Y, Rouge P, Cambillau C, J Biol Chem. 1992 Jan 5;267(1):197-203. PMID:1730588
Page seeded by OCA on Tue Nov 20 20:43:20 2007
Categories: Lathyrus ochrus | Protein complex | Bourne, Y. | Cambillau, C. | CA | GAL | MN | Lectin
