1lqa

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Image:1lqa.jpg

1lqa, resolution 1.604Å

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TAS PROTEIN FROM ESCHERICHIA COLI IN COMPLEX WITH NADPH

Overview

BACKGROUND: The protein encoded by the gene ybgI was chosen as a target, for a structural genomics project emphasizing the relation of protein, structure to function. RESULTS: The structure of the ybgI protein is a, toroid composed of six polypeptide chains forming a trimer of dimers. Each, polypeptide chain binds two metal ions on the inside of the toroid., CONCLUSION: The toroidal structure is comparable to that of some proteins, that are involved in DNA metabolism. The di-nuclear metal site could imply, that the specific function of this protein is as a hydrolase-oxidase, enzyme.

About this Structure

1LQA is a Single protein structure of sequence from Escherichia coli with NDP as ligand. Full crystallographic information is available from OCA.

Reference

Crystal structure of Escherichia coli protein ybgI, a toroidal structure with a dinuclear metal site., Ladner JE, Obmolova G, Teplyakov A, Howard AJ, Khil PP, Camerini-Otero RD, Gilliland GL, BMC Struct Biol. 2003 Sep 30;3:7. PMID:14519207

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