1lri
From Proteopedia
|
BETA-CRYPTOGEIN-CHOLESTEROL COMPLEX
Overview
Cryptogein is a small 10 kDa elicitor produced by the phytoparasitic, oomycete Phytophthora cryptogea. The protein also displays a sterol, carrier activity. The native protein crystallizes in space group P4(1)22, with unit-cell parameters a = b = 46.51, c = 134.9 A (diffraction limit:, 2.1 A). Its complex with cholesterol crystallizes in space group C222(1), with unit-cell parameters a = 30.96, b = 94.8, c = 65.3 A and a resolution, enhanced to 1.45 A. The large inner non-specific hydrophobic cavity is, able to accommodate a large variety of 3-beta-hydroxy sterols. Cryptogein, probably acts as a sterol shuttle helping the pathogen to grow and, complete its life cycle.
About this Structure
1LRI is a Single protein structure of sequence from Phytophthora cryptogea with CL and CLR as ligands. Full crystallographic information is available from OCA.
Reference
The 1.45 A resolution structure of the cryptogein-cholesterol complex: a close-up view of a sterol carrier protein (SCP) active site., Lascombe MB, Ponchet M, Venard P, Milat ML, Blein JP, Prange T, Acta Crystallogr D Biol Crystallogr. 2002 Sep;58(Pt 9):1442-7. Epub 2002, Aug 23. PMID:12198300
Page seeded by OCA on Tue Nov 20 20:48:35 2007
