1m1c
From Proteopedia
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Structure of the L-A virus
Overview
The structure of the yeast L-A virus was determined by X-ray, crystallography at 3.4 A resolution. The L-A dsRNA virus is 400 A in, diameter and contains a single protein shell of 60 asymmetric dimers of, the coat protein, a feature common among the inner protein shells of dsRNA, viruses and probably related to their unique mode of transcription and, replication. The two identical subunits in each dimer are in, non-equivalent environments and show substantially different conformations, in specific surface regions. The L-A virus decaps cellular mRNA to, efficiently translate its own uncapped mRNA. Our structure reveals a, trench at the active site of the decapping reaction and suggests a role, for nearby residues in the reaction.
About this Structure
1M1C is a Single protein structure of sequence from Saccharomyces cerevisiae virus l-a. Full crystallographic information is available from OCA.
Reference
L-A virus at 3.4 A resolution reveals particle architecture and mRNA decapping mechanism., Naitow H, Tang J, Canady M, Wickner RB, Johnson JE, Nat Struct Biol. 2002 Oct;9(10):725-8. PMID:12244300
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