This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
1fre
From Proteopedia
|
XNF7 BBOX, DEVELOPMENTAL PROTEIN, PH 7.5, 30 C, WITH ZINC, NMR, 1 STRUCTURE
Overview
Xenopus nuclear factor XNF7, a maternally expressed protein, functions in, patterning of the embryo. XNF7 contains a number of defined protein, domains implicated in the regulation of some developmental processes., Among these is a tripartite motif comprising a zinc-binding RING finger, and B-box domain next to a predicted alpha-helical coiled-coil domain., Interestingly, this motif is found in a variety of protein including, several proto-oncoproteins. Here we describe the solution structure of the, XNF7 B-box zinc-binding domain determined at physiological pH by 1H NMR, methods. The B-box structure represents the first three-dimensional, structure of this new motif and comprises a monomer have two beta-strands, two helical turns and three extended loop regions packed in a novel, ... [(full description)]
About this Structure
1FRE is a [Single protein] structure of sequence from [Xenopus laevis] with ZN as [ligand]. Full crystallographic information is available from [OCA].
Reference
Novel topology of a zinc-binding domain from a protein involved in regulating early Xenopus development., Borden KL, Lally JM, Martin SR, O'Reilly NJ, Etkin LD, Freemont PS, EMBO J. 1995 Dec 1;14(23):5947-56. PMID:8846787
Page seeded by OCA on Mon Oct 29 20:26:31 2007
