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2a4l

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Template:STRUCTURE 2a4l

Human cyclin-dependent kinase 2 in complex with roscovitine

Template:ABSTRACT PUBMED 9030780

About this Structure

2A4L is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Inhibition of cyclin-dependent kinases by purine analogues: crystal structure of human cdk2 complexed with roscovitine., De Azevedo WF, Leclerc S, Meijer L, Havlicek L, Strnad M, Kim SH, Eur J Biochem. 1997 Jan 15;243(1-2):518-26. PMID:9030780

Structural basis for specificity and potency of a flavonoid inhibitor of human CDK2, a cell cycle kinase., De Azevedo WF Jr, Mueller-Dieckmann HJ, Schulze-Gahmen U, Worland PJ, Sausville E, Kim SH, Proc Natl Acad Sci U S A. 1996 Apr 2;93(7):2735-40. PMID:8610110

Crystal structure of cyclin-dependent kinase 2., De Bondt HL, Rosenblatt J, Jancarik J, Jones HD, Morgan DO, Kim SH, Nature. 1993 Jun 17;363(6430):595-602. PMID:8510751

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