1me3
From Proteopedia
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High Resolution Crystal Structure Analysis Of Cruzain non-covalently Bound To A Hydroxymethyl Ketone Inhibitor (II)
Overview
The crystal structures of two hydroxymethyl ketone inhibitors complexed to, the cysteine protease cruzain have been determined at 1.1 and 1.2 A, resolution, respectively. These high resolution crystal structures provide, the first structures of non-covalent inhibitors bound to cruzain. A series, of compounds were prepared and tested based upon the structures providing, further insight into the key binding interactions.
About this Structure
1ME3 is a Single protein structure of sequence from Trypanosoma cruzi with P10 as ligand. Full crystallographic information is available from OCA.
Reference
Crystal structures of reversible ketone-Based inhibitors of the cysteine protease cruzain., Huang L, Brinen LS, Ellman JA, Bioorg Med Chem. 2003 Jan 2;11(1):21-9. PMID:12467703
Page seeded by OCA on Tue Nov 20 21:21:28 2007
