1mtl
From Proteopedia
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Non-productive MUG-DNA complex
Overview
Base-excision of a self-complementary oligonucleotide with central G:T, mismatches by the G:T/U-specific mismatch DNA glycosylase (MUG), generates, an unusual DNA structure which is remarkably similar in conformation to an, interstrand DNA adduct of the anti-tumor drug, cis-diamminedichloroplatinum. The abasic sugars generated by excision of, the mismatched thymines are extruded from the double-helix, and the, 'widowed' deoxyguanosines rotate so that their N7 and O6 groups protrude, into the minor groove of the duplex and restack in an interleaved, intercalative geometry, generating a kink in the helix axis.
About this Structure
1MTL is a Single protein structure of sequence from Escherichia coli. Full crystallographic information is available from OCA.
Reference
Structure of a DNA base-excision product resembling a cisplatin inter-strand adduct., Barrett TE, Savva R, Barlow T, Brown T, Jiricny J, Pearl LH, Nat Struct Biol. 1998 Aug;5(8):697-701. PMID:9699633
Page seeded by OCA on Tue Nov 20 21:41:15 2007
