1gnj
From Proteopedia
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HUMAN SERUM ALBUMIN COMPLEXED WITH CIS-5,8,11,14-EICOSATETRAENOIC ACID (ARACHIDONIC ACID)
Overview
The primary ligands of human serum albumin (HSA), an abundant plasma, protein, are non-esterified fatty acids. In vivo, the majority of fatty, acids associated with the protein are unsaturated. We present here the, first high-resolution crystal structures of HSA complexed with two, important unsaturated fatty acids, the monounsaturated oleic acid (C18:1), and the polyunsaturated arachidonic acid (C20:4). Both compounds are, observed to occupy the seven binding sites distributed across the protein, that are also bound by medium and long-chain saturated fatty acids., Although C18:1 fatty acid binds each site on HSA in a conformation almost, identical with that of the corresponding saturated compound (C18:0), the, presence of multiple cis double bonds in C20:4 induces distinct binding, ... [(full description)]
About this Structure
1GNJ is a [Single protein] structure of sequence from [Homo sapiens] with ACD as [ligand]. The following page contains interesting information on the relation of 1GNJ with [Serum Albumin]. Full crystallographic information is available from [OCA].
Reference
Crystal structures of human serum albumin complexed with monounsaturated and polyunsaturated fatty acids., Petitpas I, Grune T, Bhattacharya AA, Curry S, J Mol Biol. 2001 Dec 14;314(5):955-60. PMID:11743713
Page seeded by OCA on Mon Oct 29 20:32:04 2007
