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1gjv
From Proteopedia
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BRANCHED-CHAIN ALPHA-KETOACID DEHYDROGENASE KINASE (BCK) COMPLXED WITH ATP-GAMMA-S
Overview
Mitochondrial protein kinases (mPKs) are molecular switches that, down-regulate the oxidation of branched-chain alpha-ketoacids and, pyruvate. Elevated levels of these metabolites are implicated in disease, states such as insulin-resistant Type II diabetes, branched-chain, ketoaciduria, and primary lactic acidosis. We report a three-dimensional, structure of a member of the mPK family, rat branched-chain alpha-ketoacid, dehydrogenase kinase (BCK). BCK features a characteristic, nucleotide-binding domain and a four-helix bundle domain. These two, domains are reminiscent of modules found in protein histidine kinases, (PHKs), which are involved in two-component signal transduction systems., Unlike PHKs, BCK dimerizes through direct interaction of two opposing, nucleotide-binding domains. ... [(full description)]
About this Structure
1GJV is a [Single protein] structure of sequence from [Rattus norvegicus] with CL, MG, K and SAP as [ligands]. Active as [[1]], with EC number [2.7.1.115]. Full crystallographic information is available from [OCA].
Reference
Structure of rat BCKD kinase: nucleotide-induced domain communication in a mitochondrial protein kinase., Machius M, Chuang JL, Wynn RM, Tomchick DR, Chuang DT, Proc Natl Acad Sci U S A. 2001 Sep 25;98(20):11218-23. Epub 2001 Sep 18. PMID:11562470
Page seeded by OCA on Mon Oct 29 20:32:59 2007
Categories: Rattus norvegicus | Single protein | Chuang, D.T. | Chuang, J.L. | Machius, M. | Tomchick, D.R. | Wynn, R.M. | CL | K | MG | SAP | Mitochondrial protein kinase | Potassium | Transferase
