1n4y
From Proteopedia
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REFINED STRUCTURE OF KISTRIN
Overview
The structure of kistrin, which is a member of a homologous family of, glycoprotein IIb-IIIa (GP IIb-IIIa) antagonists and potent protein, inhibitors of platelet aggregation, has been determined by two-dimensional, nuclear magnetic resonance (NMR) spectroscopy. The 68-residue protein, consists of a series of tightly packed loops held together by six, disulfide bonds and has almost no regular secondary structure. Kistrin has, an Arg-Gly-Asp (RGD) adhesion site recognition sequence important for, binding to GP IIb-IIIa that is located at the apex of a long loop across, the surface of the protein.
About this Structure
1N4Y is a Single protein structure of sequence from Calloselasma rhodostoma. This structure superseeds the now removed PDB entry 1KST. Full crystallographic information is available from OCA.
Reference
Solution structure of kistrin, a potent platelet aggregation inhibitor and GP IIb-IIIa antagonist., Adler M, Lazarus RA, Dennis MS, Wagner G, Science. 1991 Jul 26;253(5018):445-8. PMID:1862345
Page seeded by OCA on Tue Nov 20 21:58:02 2007
