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3c2i
From Proteopedia
Contents |
The Crystal Structure of Methyl-CpG Binding Domain of Human MeCP2 in Complex with a Methylated DNA Sequence from BDNF
Template:ABSTRACT PUBMED 18313390
Disease
Known disease associated with this structure: Angelman syndrome OMIM:[300005], Encephalopathy, neonatal severe OMIM:[300005], Mental retardation, X-linked, Lubs type OMIM:[300005], Mental retardation, X-linked, syndromic 13 OMIM:[300005], Rett syndrome OMIM:[300005], Rett syndrome, preserved speech variant OMIM:[300005], Autism, susceptibility to, X-linked-3 OMIM:[300005]
About this Structure
3C2I is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.
Reference
MeCP2 binding to DNA depends upon hydration at methyl-CpG., Ho KL, McNae IW, Schmiedeberg L, Klose RJ, Bird AP, Walkinshaw MD, Mol Cell. 2008 Feb 29;29(4):525-31. PMID:18313390
Page seeded by OCA on Mon Jul 28 15:37:43 2008
Categories: Homo sapiens | Protein complex | Bird, A P. | Ho, K L. | Klose, R J. | McNae, I W. | Schmiedeberg, L. | Walkinshaw, M D. | Alternative splicing | Asx-st-motif | Chromosomal rearrangement | Disease mutation | Dna-binding | Nucleus | Phosphoprotein | Polymorphism | Protein-methylated dna complex | Repressor | Transcription regulator | Water mediated recognition
