1r49

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Template:STRUCTURE 1r49

Contents

Human topoisomerase I (Topo70) double mutant K532R/Y723F

Template:ABSTRACT PUBMED 14594810

Disease

Known disease associated with this structure: DNA topoisomerase I, camptothecin-resistant OMIM:[126420]

About this Structure

1R49 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

The role of lysine 532 in the catalytic mechanism of human topoisomerase I., Interthal H, Quigley PM, Hol WG, Champoux JJ, J Biol Chem. 2004 Jan 23;279(4):2984-92. Epub 2003 Oct 31. PMID:14594810

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