1ngr
From Proteopedia
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DEATH DOMAIN OF P75 LOW AFFINITY NEUROTROPHIN RECEPTOR, RESIDUES 334-418, NMR, 20 STRUCTURES
Overview
The intracellular domain of the p75 neurotrophin receptor (p75ICD) lacks, catalytic activity but contains a motif similar to death domains found in, the cytoplasmic regions of members of the tumor necrosis factor receptor, family and their downstream targets. Although some aspects of the, signaling pathways downstream of p75 have been elucidated recently, mechanisms of receptor activation and proximal signaling events are, unknown. Here we report the nuclear magnetic resonance (NMR) structure of, the 145 residue long p75ICD. The death domain of p75ICD consists of two, perpendicular sets of three helices packed into a globular structure. The, polypeptide segment connecting the transmembrane and death domains as well, as the serine/threonine-rich C-terminal end are highly flexible in p75ICD., Unlike the death domains involved in signaling by the TNF receptor and, Fas, p75ICD does not self-associate in solution. A surface area devoid of, charged residues in the p75ICD death domain may indicate a potential site, of interaction with downstream targets.
About this Structure
1NGR is a Single protein structure of sequence from Rattus norvegicus. Full crystallographic information is available from OCA.
Reference
NMR structure of the death domain of the p75 neurotrophin receptor., Liepinsh E, Ilag LL, Otting G, Ibanez CF, EMBO J. 1997 Aug 15;16(16):4999-5005. PMID:9305641
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