1nq3

Crystal structure of the mammalian tumor associated antigen UK114

Overview

The tumour-associated antigen UK114, isolated from goat liver, belongs to, the YER057c/YIL051c/YjgF protein family, which has members in both the, prokaryotes and eukaryotes. The crystal structure of a mammalian, representative, goat UK114, was determined, revealing a trimeric, arrangement in the crystal. It was confirmed by ultracentrifugation that, UK114 is a trimer in solution. These results are in agreement with the, published structures of homologues from unicellular organisms, but, contrast with those reported for the rat homologue of UK114, for which a, dimeric quaternary structure was proposed.

About this Structure

1NQ3 is a Single protein structure of sequence from Capra hircus. Full crystallographic information is available from OCA.

Reference

Structure and oligomeric state of the mammalian tumour-associated antigen UK114., Deriu D, Briand C, Mistiniene E, Naktinis V, Grutter MG, Acta Crystallogr D Biol Crystallogr. 2003 Sep;59(Pt 9):1676-8. Epub 2003, Aug 19. PMID:12925811

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