1t8i

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Image:1t8i.png

Template:STRUCTURE 1t8i

Contents

Human DNA Topoisomerase I (70 Kda) In Complex With The Poison Camptothecin and Covalent Complex With A 22 Base Pair DNA Duplex

Template:ABSTRACT PUBMED 15801827

Disease

Known disease associated with this structure: DNA topoisomerase I, camptothecin-resistant OMIM:[126420]

About this Structure

1T8I is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Structures of three classes of anticancer agents bound to the human topoisomerase I-DNA covalent complex., Staker BL, Feese MD, Cushman M, Pommier Y, Zembower D, Stewart L, Burgin AB, J Med Chem. 2005 Apr 7;48(7):2336-45. PMID:15801827

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