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2gs2

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Image:2gs2.png

Template:STRUCTURE 2gs2

Contents

Crystal Structure of the active EGFR kinase domain

Template:ABSTRACT PUBMED 16777603

Disease

Known disease associated with this structure: Adenocarcinoma of lung, response to tyrosine kinase inhibitor in OMIM:[131550], Nonsmall cell lung cancer, response to tyrosine kinase inhibitor in OMIM:[131550], Nonsmall cell lung cancer, susceptibility to OMIM:[131550]

About this Structure

2GS2 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

An allosteric mechanism for activation of the kinase domain of epidermal growth factor receptor., Zhang X, Gureasko J, Shen K, Cole PA, Kuriyan J, Cell. 2006 Jun 16;125(6):1137-49. PMID:16777603

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