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2r4f

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Revision as of 03:58, 29 July 2008 by OCA (Talk | contribs)
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Image:2r4f.png

Template:STRUCTURE 2r4f

Contents

Substituted Pyrazoles as Hepatselective HMG-COA reductase inhibitors

Template:ABSTRACT PUBMED 18072721

Disease

Known disease associated with this structure: Statins, attenuated cholesterol lowering by OMIM:[142910]

About this Structure

2R4F is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Substituted pyrazoles as hepatoselective HMG-CoA reductase inhibitors: discovery of (3R,5R)-7-[2-(4-fluoro-phenyl)-4-isopropyl-5-(4-methyl-benzylcarbamoyl)-2H -pyrazol-3-yl]-3,5-dihydroxyheptanoic acid (PF-3052334) as a candidate for the treatment of hypercholesterolemia., Pfefferkorn JA, Choi C, Larsen SD, Auerbach B, Hutchings R, Park W, Askew V, Dillon L, Hanselman JC, Lin Z, Lu GH, Robertson A, Sekerke C, Harris MS, Pavlovsky A, Bainbridge G, Caspers N, Kowala M, Tait BD, J Med Chem. 2008 Jan 10;51(1):31-45. Epub 2007 Dec 12. PMID:18072721

Page seeded by OCA on Tue Jul 29 06:58:34 2008

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