1w2w
From Proteopedia
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CRYSTAL STRUCTURE OF YEAST YPR118W, A METHYLTHIORIBOSE-1-PHOSPHATE ISOMERASE RELATED TO REGULATORY EIF2B SUBUNITS
Overview
Ypr118w is a non-essential, low copy number gene product from, Saccharomyces cerevisiae. It belongs to the PFAM family PF01008, which, contains the alpha-, beta-, and delta-subunits of eukaryotic translation, initiation factor eIF2B, as well as proteins of unknown function from all, three kingdoms. Recently, one of those latter proteins from Bacillus, subtilis has been characterized as a 5-methylthioribose-1-phosphate, isomerase, an enzyme of the methionine salvage pathway. We report here the, crystal structure of Ypr118w, which reveals a dimeric protein with two, domains and a putative active site cleft. The C-terminal domain resembles, ribose-5-phosphate isomerase from Escherichia coli with a similar location, of the active site. In vivo, Ypr118w protein is required for yeast cells, to ... [(full description)]
About this Structure
1W2W is a [Protein complex] structure of sequences from [Saccharomyces cerevisiae] with SO4 as [ligand]. Active as [[1]], with EC number [5.3.1.23]. Full crystallographic information is available from [OCA].
Reference
Crystal structure of yeast Ypr118w, a methylthioribose-1-phosphate isomerase related to regulatory eIF2B subunits., Bumann M, Djafarzadeh S, Oberholzer AE, Bigler P, Altmann M, Trachsel H, Baumann U, J Biol Chem. 2004 Aug 27;279(35):37087-94. Epub 2004 Jun 23. PMID:15215245
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