1sgk
From Proteopedia
|
NUCLEOTIDE-FREE DIPHTHERIA TOXIN
Overview
The crystal structure of diphtheria toxin (DT) in the absence of, nucleotide (nucleotide-free DT) has been determined at 2.3 A resolution to, a crystallographic R factor and free R factor of 18.2 and 28.2%, respectively. A comparison of this structure to the previously determined, structures of DT in complex with adenyly(3'-5')uridine monophosphate, (ApUp) and DT in complex with nicotinamide adenine dinucleotide (NAD), reveals that there are no significant movements of the two subdomains of, the catalytic (C) domain associated with dinucleotide binding. The side, chains of six residues within the active-site cleft, including Tyr65, Pro38, Tyr27, Thr23, Glu148, and Tyr54, show movements of up to 3 A upon, dinucleotide binding. In the structure of nucleotide-free DT, the, active-site loop ... [(full description)]
About this Structure
1SGK is a [Single protein] structure of sequence from [Corynephage beta]. Active as [[1]], with EC number [2.4.2.36]. Full crystallographic information is available from [OCA].
Reference
Crystal structure of nucleotide-free diphtheria toxin., Bell CE, Eisenberg D, Biochemistry. 1997 Jan 21;36(3):481-8. PMID:9012663
Page seeded by OCA on Mon Oct 29 20:48:29 2007
