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1qcs
From Proteopedia
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N-TERMINAL DOMAIN OF N-ETHYLMALEIMIDE SENSITIVE FACTOR (NSF)
Overview
N-ethylmaleimide-sensitive factor (NSF) is a hexameric ATPase essential, for eukaryotic vesicle fusion. Along with SNAP proteins, it disassembles, cis-SNARE complexes upon ATP hydrolysis, preparing SNAREs for trans, complex formation. We have determined the crystal structure of the, N-terminal domain of NSF (N) to 1.9 A resolution. N contains two, subdomains which form a groove that is a likely SNAP interaction site., Unexpectedly, both N subdomains are structurally similar to domains in, EF-Tu. Based on this similarity, we propose a model for a large, conformational change in NSF that drives SNARE complex disassembly.
About this Structure
1QCS is a Single protein structure of sequence from Cricetulus griseus with SO4 as ligand. Full crystallographic information is available from OCA.
Reference
NSF N-terminal domain crystal structure: models of NSF function., Yu RC, Jahn R, Brunger AT, Mol Cell. 1999 Jul;4(1):97-107. PMID:10445031
Page seeded by OCA on Wed Nov 21 00:34:52 2007
