1qdn

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Image:1qdn.jpg

1qdn, resolution 2.30Å

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AMINO TERMINAL DOMAIN OF THE N-ETHYLMALEIMIDE SENSITIVE FUSION PROTEIN (NSF)

Overview

The cytosolic ATPase N-ethylmaleimide-sensitive fusion protein (NSF), disassembles complexes of membrane-bound proteins known as SNAREs, an, activity essential for vesicular trafficking. The amino-terminal domain of, NSF (NSF-N) is required for the interaction of NSF with the SNARE complex, through the adaptor protein alpha-SNAP. The crystal structure of NSF-N, reveals two subdomains linked by a single stretch of polypeptide. A polar, interface between the two subdomains indicates that they can move with, respect to one another during the catalytic cycle of NSF. Structure-based, sequence alignments indicate that in addition to NSF orthologues, the p97, family of ATPases contain an amino-terminal domain of similar structure.

About this Structure

1QDN is a Single protein structure of sequence from Cricetulus griseus with SO4 and BME as ligands. Full crystallographic information is available from OCA.

Reference

Crystal structure of the amino-terminal domain of N-ethylmaleimide-sensitive fusion protein., May AP, Misura KM, Whiteheart SW, Weis WI, Nat Cell Biol. 1999 Jul;1(3):175-82. PMID:10559905

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