1qdp
From Proteopedia
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SOLUTION STRUCTURE OF ROBUSTOXIN, THE LETHAL NEUROTOXIN FROM THE FUNNEL WEB SPIDER ATRAX ROBUSTUS, NMR, 20 STRUCTURES
Overview
The solution structure of robustoxin, the lethal neurotoxin from the, Sydney funnel-web spider Atrax robustus, has been determined from 2D 1H, NMR data. Robustoxin is a polypeptide of 42 residues cross-linked by four, disulphide bonds, the connectivities of which were determined from NMR, data and trial structure calculations to be 1-15, 8-20, 14-31 and 16-42 (a, 1-4/2-6/3-7/5-8 pattern). The structure consists of a small, three-stranded, anti-parallel beta-sheet and a series of interlocking, gamma-turns at the C-terminus. It also contains a cystine knot, thus, placing it in the inhibitor cystine knot motif family of structures, which, includes the omega-conotoxins and a number of plant and animal toxins and, protease inhibitors. Robustoxin contains three distinct charged patches on, its surface, and an extended loop that includes several aromatic and, non-polar residues. Both of these structural features may play a role in, its binding to the voltage-gated sodium channel.
About this Structure
1QDP is a Single protein structure of sequence from Atrax robustus. Full crystallographic information is available from OCA.
Reference
Solution structure of robustoxin, the lethal neurotoxin from the funnel-web spider Atrax robustus., Pallaghy PK, Alewood D, Alewood PF, Norton RS, FEBS Lett. 1997 Dec 15;419(2-3):191-6. PMID:9428632
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