2aaz
From Proteopedia
Cryptococcus neoformans thymidylate synthase complexed with substrate and an antifolate
Template:ABSTRACT PUBMED 16204883
About this Structure
2AAZ is a Single protein structure of sequence from Filobasidiella neoformans. Full crystallographic information is available from OCA.
Reference
The structure of Cryptococcus neoformans thymidylate synthase suggests strategies for using target dynamics for species-specific inhibition., Finer-Moore JS, Anderson AC, O'Neil RH, Costi MP, Ferrari S, Krucinski J, Stroud RM, Acta Crystallogr D Biol Crystallogr. 2005 Oct;61(Pt 10):1320-34. Epub 2005, Sep 28. PMID:16204883
Phthalein derivatives as a new tool for selectivity in thymidylate synthase inhibition., Costi PM, Rinaldi M, Tondi D, Pecorari P, Barlocco D, Ghelli S, Stroud RM, Santi DV, Stout TJ, Musiu C, Marangiu EM, Pani A, Congiu D, Loi GA, La Colla P, J Med Chem. 1999 Jun 17;42(12):2112-24. PMID:10377217
Structure-based design of inhibitors specific for bacterial thymidylate synthase., Stout TJ, Tondi D, Rinaldi M, Barlocco D, Pecorari P, Santi DV, Kuntz ID, Stroud RM, Shoichet BK, Costi MP, Biochemistry. 1999 Feb 2;38(5):1607-17. PMID:9931028
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