1qrq
From Proteopedia
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STRUCTURE OF A VOLTAGE-DEPENDENT K+ CHANNEL BETA SUBUNIT
Overview
The integral membrane subunits of many voltage-dependent potassium, channels are associated with an additional protein known as the beta, subunit. One function of beta subunits is to modify K+ channel gating. We, have determined the structure of the conserved core of mammalian beta, subunits by X-ray crystallography at 2.8 A resolution. Like the integral, membrane component of K+ channels, beta subunits form a four-fold, symmetric structure. Each subunit is an oxidoreductase enzyme complete, with a nicotinamide co-factor in its active site. Several structural, features of the enzyme active site, including its location with respect to, the four-fold axis, imply that it may interact directly or indirectly with, the K+ channel's voltage sensor. This structure suggests a mechanism for, coupling membrane electrical excitability directly to chemistry of the, cell.
About this Structure
1QRQ is a Single protein structure of sequence from Rattus norvegicus with NDP as ligand. Full crystallographic information is available from OCA.
Reference
Structure of a voltage-dependent K+ channel beta subunit., Gulbis JM, Mann S, MacKinnon R, Cell. 1999 Jun 25;97(7):943-52. PMID:10399921
Page seeded by OCA on Wed Nov 21 00:55:30 2007
