1qu9

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spinqualitylabelsall models 1qu9, resolution 1.2Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image

1.2 A CRYSTAL STRUCTURE OF YJGF GENE PRODUCT FROM E. COLI

Overview

The YER057c/YIL051c/YjgF protein family is a set of 24 full-length, homologs, each approximately 130 residues in length, and each with no, known function or relationship to proteins of known structure. To, determine the function of this family, the structure of one member--the, YjgF protein from Escherichia coli--was solved and refined at a resolution, of 1.2 A. The YjgF molecule is a homotrimer with exact threefold symmetry., Its tertiary and quaternary structures are related to that of Bacillus, subtilis chorismate mutase, although their active sites are completely, different. The YjgF protein has an active site curiously similar to, protein tyrosine phosphatases, including a covalently modified cysteine, but it is unlikely to be functionally related. The lessons learned from, this attempt to deduce function from structure may be useful to future, projects in structural genomics.

About this Structure

1QU9 is a Single protein structure of sequence from Escherichia coli. Full crystallographic information is available from OCA.

Reference

A test case for structure-based functional assignment: the 1.2 A crystal structure of the yjgF gene product from Escherichia coli., Volz K, Protein Sci. 1999 Nov;8(11):2428-37. PMID:10595546

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