1r1a
From Proteopedia
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CRYSTAL STRUCTURE OF HUMAN RHINOVIRUS SEROTYPE 1A (HRV1A)
Overview
The structure of human rhinovirus 1A (HRV1A) has been determined to 3.2 A, resolution using phase refinement and extension by symmetry averaging, starting with phases at 5 A resolution calculated from the known human, rhinovirus 14 (HRV14) structure. The polypeptide backbone structures of, HRV1A and HRV14 are similar, but the exposed surfaces are rather, different. Differential charge distribution of amino acid residues in the, "canyon", the putative receptor binding site, provides a possible, explanation for the difference in minor versus major receptor group, specificities, represented by HRV1A and HRV14, respectively. The, hydrophobic pocket in VP1, into which antiviral compounds bind, is in an, "open" conformation similar to that observed in drug-bound HRV14. Drug, binding in HRV1A does not induce extensive conformational changes, in, contrast to the case of HRV14.
About this Structure
1R1A is a Protein complex structure of sequences from Human rhinovirus a with SUC as ligand. Full crystallographic information is available from OCA.
Reference
Crystal structure of human rhinovirus serotype 1A (HRV1A)., Kim SS, Smith TJ, Chapman MS, Rossmann MC, Pevear DC, Dutko FJ, Felock PJ, Diana GD, McKinlay MA, J Mol Biol. 1989 Nov 5;210(1):91-111. PMID:2555523
Page seeded by OCA on Wed Nov 21 01:11:33 2007
