3rdn
From Proteopedia
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NMR STRUCTURE OF THE N-TERMINAL DOMAIN WITH A LINKER PORTION OF ANTARCTIC EEL POUT ANTIFREEZE PROTEIN RD3, MINIMIZED AVERAGE STRUCTURE
Overview
Antifreeze proteins (AFPs) have the unique ability to adsorb to ice and, inhibit its growth. Many organisms ranging from fish to bacteria use AFPs, to retard freezing or lessen the damage incurred upon freezing and, thawing. The ice-binding mechanism of the long linear alpha-helical type I, AFPs has been attributed to their regularly spaced polar residues matching, the ice lattice along a pyramidal plane. In contrast, it is not known how, globular antifreeze proteins such as type III AFP that lack repeating, ice-binding residues bind to ice. Here we report the 1.25 A crystal, structure of recombinant type III AFP (QAE isoform) from eel pout, (Macrozoarces americanus), which reveals a remarkably flat amphipathic, ice-binding site where five hydrogen-bonding atoms match two ranks of, ... [(full description)]
About this Structure
3RDN is a [Single protein] structure of sequence from [Rhigophila dearborni]. Full crystallographic information is available from [OCA].
Reference
Structural basis for the binding of a globular antifreeze protein to ice., Jia Z, DeLuca CI, Chao H, Davies PL, Nature. 1996 Nov 21;384(6606):285-8. PMID:8918883
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