1rcw
From Proteopedia
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Crystal structure of CT610 from Chlamydia trachomatis
Overview
The Chlamydia protein CADD (Chlamydia protein associating with death, domains) has been implicated in the modulation of host cell apoptosis via, binding to the death domains of tumor necrosis factor family receptors., Transfection of CADD into mammalian cells induces apoptosis. Here we, present the CADD crystal structure, which reveals a dimer of seven-helix, bundles. Each bundle contains a di-iron center adjacent to an internal, cavity, forming an active site similar to that of methane mono-oxygenase, hydrolase. We further show that CADD mutants lacking critical, metal-coordinating residues are substantially less effective in inducing, apoptosis but retain their ability to bind to death domains. We conclude, that CADD is a novel redox protein toxin unique to Chlamydia species and, propose that both its redox activity and death domain binding ability are, required for its biological activity.
About this Structure
1RCW is a Single protein structure of sequence from Chlamydia trachomatis with FE as ligand. Full crystallographic information is available from OCA.
Reference
Structure of the Chlamydia protein CADD reveals a redox enzyme that modulates host cell apoptosis., Schwarzenbacher R, Stenner-Liewen F, Liewen H, Robinson H, Yuan H, Bossy-Wetzel E, Reed JC, Liddington RC, J Biol Chem. 2004 Jul 9;279(28):29320-4. Epub 2004 Apr 15. PMID:15087448
Page seeded by OCA on Wed Nov 21 01:28:43 2007
