1rfb
From Proteopedia
|
CRYSTAL STRUCTURE OF RECOMBINANT BOVINE INTERFERON-GAMMA AT 3.0 ANGSTROMS RESOLUTION
Overview
The three-dimensional crystal structure of recombinant bovine, interferon-gamma was determined using the multiple isomorphous replacement, method at 3.0 A and refined to an R factor of 19.2%. This protein, crystallizes in space group P2(1)2(1)2(1) with unit-cell parameters of a =, 42.8, b = 79.9 and c = 85.4 A. There is one functional dimer in the, asymmetric unit. The two polypeptide chains are related by a, non-crystallographic twofold symmetry axis. The secondary structure is, predominantly alpha-helical with extensive interdigitation of the, alpha-helical segments of the polypeptide chains that make up the dimer., The secondary structure, tertiary structure and topology of this molecule, are identical to the previously reported structures of recombinant rabbit, interferon-gamma and recombinant human interferon-gamma. The molecular, topology is also similar to that of murine interferon-beta. These, structural similarities strongly indicate the presence of a unique, topological feature (fold) among gamma-interferons from different species, and also among the different classes of interferons.
About this Structure
1RFB is a Single protein structure of sequence from Bos taurus. Full crystallographic information is available from OCA.
Reference
Structure of recombinant bovine interferon-gamma at 3.0 A resolution., Samudzi CT, Rubin JR, Acta Crystallogr D Biol Crystallogr. 1993 Nov 1;49(Pt 6):513-21. PMID:15299487
Page seeded by OCA on Wed Nov 21 01:33:04 2007
