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1be9
From Proteopedia
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THE THIRD PDZ DOMAIN FROM THE SYNAPTIC PROTEIN PSD-95 IN COMPLEX WITH A C-TERMINAL PEPTIDE DERIVED FROM CRIPT.
Overview
Modular PDZ domains, found in many cell junction-associated proteins, mediate the clustering of membrane ion channels by binding to their, C-terminus. The X-ray crystallographic structures of the third PDZ domain, from the synaptic protein PSD-95 in complex with and in the absence of its, peptide ligand have been determined at 1.8 angstroms and 2.3 angstroms, resolution, respectively. The structures reveal that a four-residue, C-terminal stretch (X-Thr/Ser-X-Val-COO(-)) engages the PDZ domain through, antiparallel main chain interactions with a beta sheet of the domain., Recognition of the terminal carboxylate group of the peptide is conferred, by a cradle of main chain amides provided by a Gly-Leu-Gly-Phe loop as, well as by an arginine side chain. Specific side chain interactions and a, ... [(full description)]
About this Structure
1BE9 is a [Single protein] structure of sequence from [Rattus norvegicus]. Full crystallographic information is available from [OCA].
Reference
Crystal structures of a complexed and peptide-free membrane protein-binding domain: molecular basis of peptide recognition by PDZ., Doyle DA, Lee A, Lewis J, Kim E, Sheng M, MacKinnon R, Cell. 1996 Jun 28;85(7):1067-76. PMID:8674113
Page seeded by OCA on Mon Oct 29 20:57:45 2007
