1sfo
From Proteopedia
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RNA POLYMERASE II STRAND SEPARATED ELONGATION COMPLEX
Overview
The structure of an RNA polymerase II-transcribing complex has been, determined in the posttranslocation state, with a vacancy at the growing, end of the RNA-DNA hybrid helix. At the opposite end of the hybrid helix, the RNA separates from the template DNA. This separation of nucleic acid, strands is brought about by interaction with a set of proteins loops in a, strand/loop network. Formation of the network must occur in the transition, from abortive initiation to promoter escape.
About this Structure
1SFO is a Protein complex structure of sequences from Saccharomyces cerevisiae with ZN and MG as ligands. This structure superseeds the now removed PDB entry 1R9R. Active as DNA-directed RNA polymerase, with EC number 2.7.7.6 Full crystallographic information is available from OCA.
Reference
Structural basis of transcription: separation of RNA from DNA by RNA polymerase II., Westover KD, Bushnell DA, Kornberg RD, Science. 2004 Feb 13;303(5660):1014-6. PMID:14963331
Page seeded by OCA on Wed Nov 21 02:21:11 2007
