1lay
From Proteopedia
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CRYSTAL STRUCTURE OF CYTOMEGALOVIRUS PROTEASE
Overview
Human herpesviruses are responsible for a variety of diseases. They are, divided into three subfamilies: alpha includes herpes simplex viruses, (HSV-1 and HSV-2) and varicella-zoster virus (VZV); beta includes, cytomegalovirus (CMV) and human herpesvirus-6 (HHV-6); and gamma includes, Epstein-Barr virus (EBV). Each virus encodes a serine protease that is, essential for its replication and is a potential target for therapeutic, intervention. Human CMV is a ubiquitous opportunistic pathogen that can, result in life-threatening infections in congenitally infected infants, immunocompromised individuals and immunosuppressed cancer or transplant, patients. Here we report the crystal structure of human CMV protease at, 2.5 angstroms resolution. The structure reveals a fold that has not been, ... [(full description)]
About this Structure
1LAY is a [Single protein] structure of sequence from [Cytomegalovirus]. Full crystallographic information is available from [OCA].
Reference
Unique fold and active site in cytomegalovirus protease., Qiu X, Culp JS, DiLella AG, Hellmig B, Hoog SS, Janson CA, Smith WW, Abdel-Meguid SS, Nature. 1996 Sep 19;383(6597):275-9. PMID:8805707
Page seeded by OCA on Mon Oct 29 21:03:15 2007
