1hez
From Proteopedia
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ANTIBODY-ANTIGEN COMPLEX
Overview
BACKGROUND: Peptostreptococcus magnus protein L (PpL) is a multidomain, bacterial surface protein whose presence correlates with virulence. It, consists of up to five homologous immunoglobulin binding domains that, interact with the variable (VL) regions of kappa light chains found on two, thirds of mammalian antibodies. RESULTS: We refined the crystal structure, of the complex between a human antibody Fab fragment (2A2) and a single, PpL domain (61 residues) to 2.7 A. The asymmetric unit contains two Fab, molecules sandwiching a single PpL domain, which contacts similar VL, framework regions of two light chains via independent interfaces. The, residues contacted on VL are remote from the hypervariable loops. One, PpL-Vkappa interface agrees with previous biochemical data, while the, ... [(full description)]
About this Structure
1HEZ is a [Protein complex] structure of sequences from [Finegoldia magna] and [Homo sapiens] with IMD as [ligand]. Full crystallographic information is available from [OCA].
Reference
Complex between Peptostreptococcus magnus protein L and a human antibody reveals structural convergence in the interaction modes of Fab binding proteins., Graille M, Stura EA, Housden NG, Beckingham JA, Bottomley SP, Beale D, Taussig MJ, Sutton BJ, Gore MG, Charbonnier JB, Structure. 2001 Aug;9(8):679-87. PMID:11587642
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