1swm

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Image:1swm.gif

1swm, resolution 1.8Å

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X-RAY CRYSTAL STRUCTURE OF THE FERRIC SPERM WHALE MYOGLOBIN: IMIDAZOLE COMPLEX AT 2.0 ANGSTROMS RESOLUTION

Overview

The X-ray crystal structure of the ferric sperm whale (Physeter catodon), myoglobin:imidazole complex has been refined at 2.0 A resolution, to a, final R-factor of 14.8%. The overall conformation of the protein is little, affected by binding of the ligand. Imidazole is co-ordinated to the heme, iron at the distal site, and forces distinguishable local changes in the, surrounding protein residues. His64(E7) swings out of the distal pocket, and becomes substantially exposed to the solvent: nevertheless, it, stabilizes the exogenous ligand by hydrogen bonding. The side-chains of, residues Arg45(CD3) and Asp60(E3) are also affected by imidazole, association.

About this Structure

1SWM is a Single protein structure of sequence from Physeter catodon with AZI, SO4 and HEM as ligands. Full crystallographic information is available from OCA.

Reference

X-ray crystal structure of the ferric sperm whale myoglobin: imidazole complex at 2.0 A resolution., Lionetti C, Guanziroli MG, Frigerio F, Ascenzi P, Bolognesi M, J Mol Biol. 1991 Feb 5;217(3):409-12. PMID:1994031

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