User:Amir Mitchell/Gal4
From Proteopedia
Contents |
Galactose Metabolism Pathway
Gal4 is a yeast transcription factor. This positive regulator induces the Leloir pathway, a metabolic pathway for the conversion of β-d-galactose to the glucose-1-phosphate. The pathway is comprised of four enzymes: (1) Galactokinase (Gal1), (2) Galactose-1-phosphate uridylyltransferase (Gal7) and (3) Galactose mutarotase and UDP-galactose-4-epimerase both contaied by a single polypeptide chain (Gal10). Two additional regulatory proteins, Gal80 and Gal3, interact with Gal4 to affect the expression of the pathway. Together this set of structural and regulatory genes has served as a model system for the study of transcription regulation in eukaryotes.
Regulation of the Pathway
The Gal4 Transcription factor
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| Resources: | FirstGlance, OCA, RCSB, PDBsum | ||||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||||
zinc finger
Mutation in Gal4
gal81c - constitutive [1]
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| 1d66, resolution 2.70Å () | |||||||||
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| Resources: | FirstGlance, OCA, RCSB, PDBsum | ||||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||||
References
Structure and Function of Enzymes of the Leloir Pathway for Galactose Metabolism, J. Biol. Chem 2003 [2]
Galactose metabolic pathway, KEGG database [3].
