1w66

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spinqualitylabelsall models 1w66, resolution 1.08Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image

STRUCTURE OF A LIPOATE-PROTEIN LIGASE B FROM MYCOBACTERIUM TUBERCULOSIS

Overview

Lipoic acid is essential for the activation of a number of protein, complexes involved in key metabolic processes. Growth of Mycobacterium, tuberculosis relies on a pathway in which the lipoate attachment group is, synthesized from an endogenously produced octanoic acid moiety. In, patients with multiple-drug-resistant M. tuberculosis, expression of one, gene from this pathway, lipB, encoding for octanoyl-[acyl carrier, protein]-protein acyltransferase is considerably up-regulated, thus making, it a potential target in the search for novel antiinfectives against, tuberculosis. Here we present the crystal structure of the M. tuberculosis, LipB protein at atomic resolution, showing an unexpected thioether-linked, active-site complex with decanoic acid. We provide evidence that the, ... [(full description)]

About this Structure

1W66 is a [Single protein] structure of sequence from [Mycobacterium tuberculosis] with DKA as [ligand]. Full crystallographic information is available from [OCA].

Reference

The Mycobacterium tuberculosis LipB enzyme functions as a cysteine/lysine dyad acyltransferase., Ma Q, Zhao X, Nasser Eddine A, Geerlof A, Li X, Cronan JE, Kaufmann SH, Wilmanns M, Proc Natl Acad Sci U S A. 2006 Jun 6;103(23):8662-7. Epub 2006 May 30. PMID:16735476

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