1l9w
From Proteopedia
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CRYSTAL STRUCTURE OF 3-DEHYDROQUINASE FROM SALMONELLA TYPHI COMPLEXED WITH REACTION PRODUCT
Overview
The type I 3-dehydroquinate dehydratase (DHQase) which catalyses the, reversible dehydration of 3-dehydroquinic acid to 3-dehydroshikimic acid, is involved in the shikimate pathway for the biosynthesis of aromatic, compounds. The shikimate pathway is absent in mammals, which makes, structural information about DHQase vital for the rational design of, antimicrobial drugs and herbicides. The crystallographic structure of the, type I DHQase from Salmonella typhi has now been determined for the native, form at 1.78 A resolution (R = 19.9%; R(free) = 24.7%). The structure of, the modified enzyme to which the product has been covalently bound has, also been determined but in a different crystal form (2.1 A resolution; R, = 17.7%; R(free) = 24.5%). An analysis of the three available crystal, ... [(full description)]
About this Structure
1L9W is a [Single protein] structure of sequence from [Salmonella typhi] with DHS as [ligand]. Active as [[1]], with EC number [4.2.1.10]. Full crystallographic information is available from [OCA].
Reference
Comparison of different crystal forms of 3-dehydroquinase from Salmonella typhi and its implication for the enzyme activity., Lee WH, Perles LA, Nagem RA, Shrive AK, Hawkins A, Sawyer L, Polikarpov I, Acta Crystallogr D Biol Crystallogr. 2002 May;58(Pt 5):798-804. Epub 2002, Apr 26. PMID:11976491
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