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1ua7

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Image:1ua7.gif

1ua7, resolution 2.21Å

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Crystal Structure Analysis of Alpha-Amylase from Bacillus Subtilis complexed with Acarbose

Overview

The crystal structure of Bacillus subtilis alpha-amylase, in complex with, the pseudotetrasaccharide inhibitor acarbose, revealed an hexasaccharide, in the active site as a result of transglycosylation. After comparison, with the known structure of the catalytic-site mutant complexed with the, native substrate maltopentaose, it is suggested that the present structure, represents a mimic intermediate in the initial stage of the catalytic, process.

About this Structure

1UA7 is a Single protein structure of sequence from Bacillus subtilis with CA as ligand. Active as Alpha-amylase, with EC number 3.2.1.1 Full crystallographic information is available from OCA.

Reference

Crystal structure of Bacillus subtilis alpha-amylase in complex with acarbose., Kagawa M, Fujimoto Z, Momma M, Takase K, Mizuno H, J Bacteriol. 2003 Dec;185(23):6981-4. PMID:14617662

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