Transcription Termination Factor Rho

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Transcription termination factor Rho is a ring-shaped RNA-DNA helicase that induces release of transcription complexes at specific locci of bacterial genomes. Several structures of Rho in various liganted states haven been solved by X-ray cristallography by the Berger lab (Berkeley). Here is one representation showing the Rho hexamer in a closed state and with RNA fragments occupying both its primary and secondary binding sites.

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Template:STRUCTURE Rho1.pdb

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Michal Harel, Eric Martz, Marc Boudvillain, David Canner

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